Prolonged fever after pleural instillation of Corynebacterium parvum (Coparvax).

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Prolonged fever after pleural instillation of Corynebacterium parvum (Coparvax).

CASE I A 70 year old woman presented with a pleural effusion containing undifferentiated carcinoma cells. Biopsy of an enlarged cervical gland yielded material with the histological features of adenocarcinoma. She had a previous history of systemic lupus erythematosus and seropositive arthritis. Corynebacterium parvum (7 mg in 20 ml normal saline) was instilled into the pleural cavity after asp...

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Intrapleural Corynebacterium parvum for malignant pleural effusions.

A pilot study of topical (intrapleural) treatment with Corynebacterium parvum was carried out in 10 patients with malignant pleural effusions complicating primary or secondary neoplasms and necessitating frequent thoracocentesis for symptomatic relief. The method was aspiration of all intrapleural fluid except a small portion left for dilution, and then injection of 7 mg of a preparation of Cor...

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Treatment of malignant ascitic and pleural effusion with Corynebacterium parvum.

Six patients with malignant effusions, five from adenocarcinomas and one from a melanoma, were treated by intrapleural or intraperitoneal Corynebacterium parvum. In each case there was a definite reduction in the effusions with a significant decrease in the number of malignant cells; in most cases the effusions stopped completely. Although none of the patients lived for more than a year after t...

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Further experience of Corynebacterium parvum in malignant pleural effusion.

The outcome of drug induced pleurodesis has been evaluated in a non-randomised retrospective study of 67 patients with recurrent malignant pleural effusions treated during 1976-83. Fourteen died within 30 days of treatment. Of the remaining 53 patients, 26 studied during 1976-80 were treated with intrapleural mustine hydrochloride, while 27 studied during 1978-83 were treated with intrapleural ...

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Corynebacterium parvum versus tetracycline as pleural sclerosing agents in rabbits.

Tetracycline has been one of the most commonly used agents for producing a pleurodesis. However, it is no longer available due to more stringent requirements on the manufacturing process. The objective of this project was to determine whether Corynebacterium parvum is an effective sclerosant in an experimental model in rabbits. The following medications were instilled intrapleurally in anaesthe...

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ژورنال

عنوان ژورنال: Thorax

سال: 1987

ISSN: 0040-6376

DOI: 10.1136/thx.42.10.823